PF 03716556

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PF 3716556 是一种有效的选择性 P-CAB（钾竞争性酸阻断剂），在离子渗漏和离子严密测定中抑制猪 H+,K+-ATPase 活性的 pIC50 分别为 6.026 和 7.095。

PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.

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Animal Model:Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg Administration:Intraduodenal administration; once Result:Inhibited gastric acid secretion in a dose-dependent manner.

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Endocrinology/Hormones

ATPase

H+/K+-ATPase

Metabolic Disease

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928774-43-0

394.48

C22H26N4O3

>98% (HPLC)

Ethanol: 79 mg/mL (200.26 mM); DMSO: 79 mg/mL (200.26 mM)

CC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO

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(-20℃)

With Ice Pack

≥ 2 years